SARAs
SARAs are the Sar1-ADP-ribosylation factor family of small GTPases, which govern the intracellular trafficking of proteins in coat protein (COP)-coated vesicles.
SARAs family of proteins initiates the intracellular transport of proteins in COPII (coat protein)-coated vesicles.
Members
| SARA1 | SARA2 |
See also
COPI vescicles
COPII vesicles
Pathology
germline mutations of the SARA1 and SARA2 genes in
- chylomicron retention disease (MIM.246700)
- Anderson disease (MIM.607689)
- chylomicron retention disease with Marinesco-Sjogren syndrome (MIM.607692)
References
Shoulders CC, Stephens DJ, Jones B. The intracellular transport of chylomicrons requires the small GTPase, Sar1b. Curr Opin Lipidol. 2004 Apr;15(2):191-7. PMID: #15017362#