- Human pathology

Home > A. Molecular pathology > glucuronidation


Monday 22 November 2004

Glucuronidation represents a major pathway which enhances the elimination of many lipophilic xenobiotics and endobiotics to more water-soluble compounds.

UDP-glucuronosyltransferases (UDPGTs) catalyze the addition of the glycosyl group from a nucleotide sugar to a small hydrophobic molecule (aglycone).

The conserved superfamily proteins all contain a 44-amino acid signature sequence in their C-terminal halves.


- germline mutations of UGT1A1 in Crigler-Najjar disease