DNA variants

Genic variants are more likely to alter gene function and affect disease risk than those that occur outside genes.

See also

 low allele frequency variants (LAFV)
 DNA variant annotation
 genome-wide association studies
 HapMap ENCODE
 functionally important regions
 genotyping
 gene-centric genome-wide association studies

Types

 missense variants

See also

 variants of unknown significance (VUSs)

Videos

 Variant analysis by Ingenuity

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References

 Jorgenson E, Witte JS. A gene-centric approach to genome-wide association studies. Nat Rev Genet. 2006 Nov;7(11):885-91. PMID: 17047687

 Gibson G, Dworkin I. Uncovering cryptic genetic variation. Nat Rev Genet. 2004 Sep;5(9):681-90. PMID: 15372091