CHGA
MIM.118910 14q32
Chromogranin A (CHGA) is a protein costored and coreleased with catecholamines from storage granules in the adrenal medulla.
CHGA is a protein costored and coreleased with parathyroid hormone (PTH) from storage granules in the parathyroid gland.
Expression in tumors
Chromogranin A is secreted by a great variety of peptide-producing endocrine neoplasms:
paragangliomas: adrenal pheochromocytoma, aortic-body tumor
parathyroid adenoma
medullary thyroid carcinoma
carcinoid tumors
oat-cell lung cancer
pancreatic islet-cell tumors
References
Kim T, Tao-Cheng JH, Eiden LE, Peng Loh Y. The role of chromogranin A and the control of secretory granule genesis and maturation. Trends Endocrinol Metab. 2003 Mar;14(2):56-7. PMID: #12591171#
Day R, Gorr SU. Secretory granule biogenesis and chromogranin A: master gene, on/off switch or assembly factor? Trends Endocrinol Metab. 2003 Jan;14(1):10-3. PMID: #12475606#