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eosinophilic esophagitis

Monday 18 October 2004

eosinophilic oesophagitis, allergic esophagitis, allergic eosinophilic esophagitis


- Eosinophilic esophagitis


- eosoniphils in surface epithelium

  • High number of eosinophils (>20/hpf)
  • Eosinophil number highest proximally
  • Predominance of eosinophils toward luminal surface
  • eosinophilic microabscesses
  • surface eosinophilic slough

- eosinophilic microabscess formation
- eosinophilic superficial concentration
- high intraepithelial eosinophil counts
- intraepithelial mast cells (17204948)
- IgE-bearing cells (17204948)

Differential diagnosis

- gastroesophageal reflux disease (GERD)

  • peptic esophagitis

See also

- eosinophilic infiltrations
- eosinophilic digestive diseases
- eosinophilic gastroenteropathies
- esophagitis
- eosinophilic enteropathies


- Furuta GT, Liacouras CA, Collins MH, Gupta SK, Justinich C, Putnam PE, Bonis P, Hassall E, Straumann A, Rothenberg ME; First International Gastrointestinal Eosinophil Research Symposium (FIGERS) Subcommittees. Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment. Gastroenterology. 2007 Oct;133(4):1342-63. Epub 2007 Aug 8. PMID: 17919504

- Antonioli DA, Furuta GT. Allergic eosinophilic esophagitis: a primer for pathologists. Semin Diagn Pathol. 2005 Nov;22(4):266-72. PMID: 16939054

- Kirsch R, Bokhary R, Marcon MA, Cutz E. Activated mucosal mast cells differentiate eosinophilic (allergic) esophagitis from gastroesophageal reflux disease. J Pediatr Gastroenterol Nutr. 2007 Jan;44(1):20-6. PMID: 17204948