Home > E. Pathology by systems > Urinary system > Urinary bladder > megacystis
megacystis
Tuesday 12 October 2004
Etioogy
fetal urethral obstruction (obstructive megacystis)
- meconium in the urinary bladder (congenital rectovesical fistula)
- urethral atresia (agenesis of the posterior urethra) with or without anorectal agenesis
- posterior urethral valve
non-obstructive megacystis
- intestinal neuronal dysplasia
- vesical myopathy (visceral myopathy)
-
megacystis-microcolon-intestinal hypoperistalsis syndrome (MMIHS)
- trisomy 18
-
megacystis-microcolon-intestinal hypoperistalsis syndrome (MMIHS)
chromosomal anomalies
- trisomy 13
- trisomy 18
- trisomy 21
Mouse models
mgb mouse: transgenic mutant mouse model with in utero megabladder, hydroureteronephrosis, chronic renal failure secondary to obstructive uropathy (primary defect in bladder smooth muscle development) (17202422)
See also
Prune-Belly sequence
Case records
Case record #10087
Case record #11183: megacystis-microcolon syndrome
Case record #11598: Megacystis in urethral obstruction sequence (UOS) with prune belly syndrome
References
McHugo J, Whittle M. Enlarged fetal bladders: aetiology, management and outcome. Prenat Diagn. 2001 Nov;21(11):958-63. PMID: 11746149