melanoma

Localization

 cutaneous melanoma
 non-cutaneous melanomas

• meningeal melanoma
• uveal melanoma

Images

 Melanoma FNA

• https://twitter.com/Sara_Jiang/status/736239982952747008

 large cell melanoma

• https://twitter.com/JMGardnerMD/status/1459672563571998724

Appearance

 large cell melanoma

• https://twitter.com/JMGardnerMD/status/1459672563571998724

 fusiform cell melanoma

Digital cases

 UI:1827 - Cutaneous malignant melanoma, solar damage
 UI:347 - Cutaneous malignant melanoma.
 JRC:111 : Metastatic malignant melanoma in a lymph node.
 JRC:3168 : Metastatic malignant melanoma in the ovary.
 JRC:10632 : Cutaneous spindle cell melanoma.
 JRC:10642 : Cutaneous melanoma (In Situ Hutchinson).
 JRC:10647 : Cutaneous melanoma.
 JRC:10650 : Cutaneous melanoma in a child.
 JRC:14087 : Pulmonary metastasis of a melanoma.
 JRC:14614 : Metastatic malignant melanoma (vs primary CNS-type melanoma vs malignant epithelioid schwannoma).
 Malignant Melanoma, Liver FNA by Ed Euthman

Melanoma incidence has been rising steadily for decades, whereas mortality rates have remained flat.

Differential diagnosis

 Ancillary tests, such as fluorescent in situ hybridization (FISH), are now being used to help differentiate melanomas from melanocytic nevi. Multicolor FISH has been shown to distinguish between these 2 with 86.7% sensitivity and 95.4% specificity. (21716079)

Cytology of melanoma by FNA

 Malignant Melanoma, Liver FNA by Ed Euthman

Reporting

 https://www.melanoma.org/understand-melanoma/diagnosing-melanoma/melanoma-pathology

Sequencing

Video : Comparison of primary and metastatic acral melanoma by whole genome sequencing.

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References

 Assessment of copy number status of chromosomes 6 and 11 by FISH provides independent prognostic information in primary melanoma. North JP, Vetto JT, Murali R, White KP, White CR Jr, Bastian BC. Am J Surg Pathol. 2011 Aug;35(8):1146-50. PMID: 21716079

 Clinical Relevance of Detection of Lymphovascular Invasion in Primary Melanoma Using Endothelial Markers D2-40 and CD34. Rose AE, Christos PJ, Lackaye D, Shapiro RL, Berman R, Mazumdar M, Kamino H, Osman I, Darvishian F. Am J Surg Pathol. 2011 Aug 29. PMID: 21881483