Home > E. Pathology by systems > Digestive system > Colon and rectum > cystic fibrosis-associated colonopathy
cystic fibrosis-associated colonopathy
Friday 27 June 2003
An epidemic of fibrosing colonopathy, a new disease caused by the prolonged administration of excessive doses of pancreatic enzymes, was first reported in 1994. More than 60 cases were known to occur worldwide before dosage guidelines were enforced.
Predisposing factors
young age
previous intestinal surgery
meconium ileus equivalent
use of H2 blockers, corticosteroids, and DNase.
Synopsis
foreshortened colon
strictures
marked submucosal fibrosis
ascites
nodular hyperplasia of the liver
Microscopical synopsis
eosinophilia
mild cryptitis
epithelial regeneration
interruption of the muscularis mucosa
Differential diagnosis
Crohn disease
ischemic bowel disease
See also
cystic fibrosis-associated colitis
