NR4A3
MIM.600542 9q22
Pathology
Fusion proteins in myxoid chondrosarcoma
- NR4A3/EWSR1 fusion gene by t(9;22)(q22;q12)
- NR4A3/TAF15
- NR4A3/TCF12
The EWSR1/NOR-1 fusion protein is encoded by the t(9;22) chromosomal translocation found in approximately 75% of extraskeletal myxoid chondrosarcoma (EMC) tumors.
References
Filion C, Labelle Y. The oncogenic fusion protein EWS/NOR-1 induces transformation of CFK2 chondrogenic cells. Exp Cell Res. 2004 Jul 15;297(2):585-92. PMID: #15212958#
Panagopoulos I, Mertens F, Isaksson M, Domanski HA, Brosjo O, Heim S, Bjerkehagen B, Sciot R, Dal Cin P, Fletcher JA, Fletcher CD, Mandahl N. Molecular genetic characterization of the EWS/CHN and RBP56/CHN fusion genes in extraskeletal myxoid chondrosarcoma. Genes Chromosomes Cancer. 2002 Dec;35(4):340-52. PMID: #12378528#
Clark, J.; Benjamin, H.; Gill, S.; Sidhar, S.; Goodwin, G.; Crew, J.; Gusterson, B. A.; Shipley, J.; Cooper, C. S. : Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma. Oncogene 12: 229-235, 1996. PubMed ID : #8570200#