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carcinoma of the ampulla of Vater
Tuesday 13 July 2004
Mismatch repair
MSI-phenotype is an early event, which develops at the stage of adenoma and is reliably detectable in the precursor lesion. The MMR deficient molecular pathway of carcinogenesis is associated with a histopathologic phenotype in ampullary cancer, similar to the one that has been well described in colon cancer. (19252434)
References
Histopathologic features and microsatellite instability of cancers of the papilla of vater and their precursor lesions. Ruemmele P, Dietmaier W, Terracciano L, Tornillo L, Bataille F, Kaiser A, Wuensch PH, Heinmoeller E, Homayounfar K, Luettges J, Kloeppel G, Sessa F, Edmonston TB, Schneider-Stock R, Klinkhammer-Schalke M, Pauer A, Schick S, Hofstaedter F, Baumhoer D, Hartmann A. Am J Surg Pathol. 2009 May;33(5):691-704. PMID: 19252434
Zhou H, Schaefer N, Wolff M, Fischer HP. Carcinoma of the Ampulla of Vater: Comparative Histologic/Immunohistochemical Classification and Follow-up. Am J Surg Pathol. 2004 Jul;28(7):875-882. PMID: 15223956
