cutaneous clear cell tumors

Examples

 Clear cell hidradenoma

• https://twitter.com/drmalaybajpai/status/849881029791719424

Practice points

· clear cell neoplasms of the skin comprise a broad variety of pri-mary and metastatic, benign and malignant lesions of epithelial, mesenchymal, melanocytic origins
· correct diagnosis relies upon careful analysis of histologic fea¬tures with the frequent use of supporting immunohistochemical and even molecular studies
· adnexal clear cell carcinoma with comedonecrosis is a newly described, clinically aggressive teston histologically characterized by a dermal proliferation with zonation of cytologic features (peripheral squamous cells, intermediate clear cells, and central necrosis)
· cutaneous clear colt sarcoma may be distinguished from clear cell melanoma by identification of the characteristic cytogenetic hallmark t(12,22)(q13;q12) resulting in a chimeric EWSR//ATF/ gene
· care must be taken to avoid misinterpretation of epidermotropic metastases from an internat organ clear cell neoplasm as a pri-mary cutaneous pagetoid disease. Caution should be exerted when evaluating pagetoid lesions in patients with known primary matignancies

Types

  epidermal tumors / epidermal neoplasms
 * clear cell acanthoma

• seborrhoeic keratosis
• basal cell carcinoma (BCC)
• cutaneous squamous cell carcinoma (SCC)

 adnexal tumors / adnexal neoptasms

• follicular tumors -sebaceous tumors
  • trichoblastoma
  • trichilemmoma
  • trichilemmal carcinoma
  • sebaceous adenoma
  • sebaceous carcinoma

• cutaneous glandular tumors
  • clear cell syringoma
  • clear cell hidradenoma
  • clear cell eccrine carcinoma ( hidradenocarcinoma )
  • eccrine fibroadenoma with clear cells
  • clear oeil poroma / dermal duct tumour
  • clear cell porocarcinoma
  • Paget disease (mammary and extramarnmary)

Myoepithetial
Clear cell myoepithelioma

Fibrohistiocytic
Clear oeil dermatofibroma
Clear cell atypical fibroxanthoma
Xanthoma with clear cell change

Mesenchymal neoplasms
Neurofibroma
Clear cell granular oeil tumour
Clear oeil fibrous papule
Cellular neurothekeoma
Primary cutaneous perivascular epithelioid cell tumour (PEComa)
Distinctive dermal clear cell mesenchymal neoplasm
Clear cell sarcoma
Epithelioid leiomyosarcoma
Epithelioid angiosarcoma
(Malignant) glomus tumour
Hemangioblastoma

Melanocytic
Balloon cell nevus
Clear cell melanoma

Short list

 benign

• Primary cutaneous perivascular epithelioid cell tumour (PEComa )
• dermal clear cell mesenchymal tumor

 malignant

• clear cell sarcoma
• malignant PEComa

See also

 cutaneous tumors
 clear cell tumors

References

 Dr GeronimGe//twitter.com/GeronimoJrLapac/status/813681842318700544