RUNX3

Runx3 plays a role during the development of sensory neurons and T cells and regulates transforming growth factor beta (TGF-beta) signaling in dendritic cells.

Pathology

 A tumor suppressor function has been attributed to RUNX3, a member of the RUNXs family of transcription factors.

 RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer. (16818622)

Knockout mice:

 Runx3 knockout mice (KO mice) spontaneously develop inflammatory bowel disease (IBD) characterized by leukocyte infiltration, mucosal hyperplasia, formation of lymphoid clusters, and increased production of IgA.

• Additionally, at a considerably older age (8 months), the KO mice also develop progressive hyperplasia of the gastric mucosa associated with disturbed epithelial differentiation and cellular hyaline degeneration.

See also:

 RUNXs (RUNX1, RUNX2, and RUNX3)
 interacting partner CBF-beta

References

 Lau QC, Raja E, Salto-Tellez M, Liu Q, Ito K, Inoue M, Putti TC, Loh M, Ko TK, Huang C, Bhalla KN, Zhu T, Ito Y, Sukumar S. RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer. Cancer Res. 2006 Jul 1;66(13):6512-20. PMID: 16818622

 Brenner O, Levanon D, Negreanu V, Golubkov O, Fainaru O, Woolf E, Groner Y. Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasia. Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):16016-21. PMID: 15514019

 Bae SC, Choi JK. Tumor suppressor activity of RUNX3. Oncogene. 2004 May 24;23(24):4336-40. PMID: 15156190