ETV4

Pathology

 EWSR1/ETV4 fusion gene by a t(17;22)(q12;q12) in

• extra-osseous Ewing sarcoma
• undifferentiated sarcoma of infancy (8834175)

 TMPRSS2/ETV4 gene fusion in prostatic carcinoma (prostate cancer) (17390040, 16585160)

 overexpression in tumors

• pulmonary carcinomas (non-small cell lung cancer)
• colorectal adenocarcinomas (colon cancer)
• oral squamous cell carcinoma (OSCC)

See also

 ETVs and ETSs

References

 Winnes M, Lissbrant E, Damber JE, Stenman G. Molecular genetic analyses of the TMPRSS2-ERG and TMPRSS2-ETV1 gene fusions in 50 cases of prostate cancer. Oncol Rep. 2007 May;17(5):1033-6. PMID: 17390040

 Tomlins SA, Mehra R, Rhodes DR, Smith LR, Roulston D, Helgeson BE, Cao X, Wei JT, Rubin MA, Shah RB, Chinnaiyan AM. TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer. Cancer Res. 2006 Apr 1;66(7):3396-400. PMID: 16585160

 Szuhai K, Ijszenga M, Tanke HJ, Rosenberg C, Hogendoorn PC. Molecular cytogenetic characterization of four previously established and two newly established Ewing sarcoma cell lines. Cancer Genet Cytogenet. 2006 Apr 15;166(2):173-9. PMID: 16631476

 Shindoh M, Higashino F, Kohgo T. E1AF, an ets-oncogene family transcription factor. Cancer Lett. 2004 Dec 8;216(1):1-8. PMID: 15500943

 Ishida S, Yoshida K, Kaneko Y, Tanaka Y, Sasaki Y, Urano F, Umezawa A, Hata J, Fujinaga K. The genomic breakpoint and chimeric transcripts in the EWSR1-ETV4/E1AF gene fusion in Ewing sarcoma. Cytogenet Cell Genet. 1998;82(3-4):278-83. PMID: 9858836

 Urano F, Umezawa A, Yabe H, Hong W, Yoshida K, Fujinaga K, Hata J. Molecular analysis of Ewing’s sarcoma: another fusion gene, EWS-E1AF, available for diagnosis. Jpn J Cancer Res. 1998 Jul;89(7):703-11. PMID: 9738976

 Urano F, Umezawa A, Hong W, Kikuchi H, Hata J. A novel chimera gene between EWS and E1A-F, encoding the adenovirus E1A enhancer-binding protein, in extraosseous Ewing’s sarcoma. Biochem Biophys Res Commun. 1996 Feb 15;219(2):608-12. PMID: 8605035

 Kaneko Y, Yoshida K, Handa M, Toyoda Y, Nishihira H, Tanaka Y, Sasaki Y, Ishida S, Higashino F, Fujinaga K. Fusion of an ETS-family gene, EIAF, to EWS by t(17;22)(q12;q12) chromosome translocation in an undifferentiated sarcoma of infancy. Genes Chromosomes Cancer. 1996 Feb;15(2):115-21. PMID: 8834175