undifferentiated sarcomas

Definition: Undifferentiated sarcomas are primitive mesenchymal tumors that cannot be classified among standardized histopathologic entities. Whether they represent a homogeneous group with common histogenesis and clinical behavior or comprise a variety of tumors able to differentiate along specific maturative lineages is still debated.

Primitive undifferentiated sarcomas occur in the trunk, behave aggressively, and express nestin. (19647855)

Spindle cell undifferentiated sarcomas occur in extremities, have a favorable outcome, resemble fibrosarcomas, and have similarly low survivin levels and display CD105-positive vascular spaces, which may represent an early hemangiopericytomatous pattern. (19647855)

Types

 undifferentiated small round cell sarcomas
 undifferentiated large round cell sarcomas
 undifferentiated fusiform cell sarcomas

See also

 undifferentiated tumors

• undifferentiated carcinomas

Open References

 Application of Immunohistochemistry in Undifferentiated Neoplasms. A Practical Approach. doi : 10.5858/arpa.2016-0518-RA
http://www.archivesofpathology.org/doi/pdf/10.5858/arpa.2016-0518-RA

References

 Undifferentiated sarcoma: does it exist? A clinicopathologic study of 7 pediatric cases and review of literature. Alaggio R, Bisogno G, Rosato A, Ninfo V, Coffin CM. Hum Pathol. 2009 Nov;40(11):1600-10. PMID: 19647855

 Pawel BR, Hamoudi AB, Asmar L, Newton WA Jr, Ruymann FB, Qualman SJ, Webber BL, Maurer HM. Undifferentiated sarcomas of children: pathology and clinical behavior—an Intergroup Rhabdomyosarcoma study. Med Pediatr Oncol. 1997 Sep;29(3):170-80. PMID: 9212841