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undifferentiated sarcomas

Monday 28 June 2004

Definition: Undifferentiated sarcomas are primitive mesenchymal tumors that cannot be classified among standardized histopathologic entities. Whether they represent a homogeneous group with common histogenesis and clinical behavior or comprise a variety of tumors able to differentiate along specific maturative lineages is still debated.

Primitive undifferentiated sarcomas occur in the trunk, behave aggressively, and express nestin. (19647855)

Spindle cell undifferentiated sarcomas occur in extremities, have a favorable outcome, resemble fibrosarcomas, and have similarly low survivin levels and display CD105-positive vascular spaces, which may represent an early hemangiopericytomatous pattern. (19647855)


- undifferentiated small round cell sarcomas
- undifferentiated large round cell sarcomas
- undifferentiated fusiform cell sarcomas

See also

- undifferentiated tumors

Open References

- Application of Immunohistochemistry in Undifferentiated Neoplasms. A Practical Approach. doi : 10.5858/arpa.2016-0518-RA


- Undifferentiated sarcoma: does it exist? A clinicopathologic study of 7 pediatric cases and review of literature. Alaggio R, Bisogno G, Rosato A, Ninfo V, Coffin CM. Hum Pathol. 2009 Nov;40(11):1600-10. PMID: 19647855

- Pawel BR, Hamoudi AB, Asmar L, Newton WA Jr, Ruymann FB, Qualman SJ, Webber BL, Maurer HM. Undifferentiated sarcomas of children: pathology and clinical behavior—an Intergroup Rhabdomyosarcoma study. Med Pediatr Oncol. 1997 Sep;29(3):170-80. PMID: 9212841