MAP3K5
MIM.602448 6q23
Function
MAP3K5 encodes a mitogen-activated protein kinase kinase kinase (MAPKKKs or MAP3Ks) of the JNK/MAPK signaling pathway
Pathology
amplification and overexpression of ASK1 or MAP3K5 gene at 6q23 band in malignant fibrous histiocytoma (MFH) (#15034865#)
- MAP3K5 could inhibit the adipocytic differentiation process of the tumor cells. (#15034865#)
- Treatment of a cell line with specific inhibitors of ASK1 protein resulted in the bypass of the differentiation block and induction of a strong adipocytic differentiation. (#15034865#)