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transient acantholytic dermatosis

Wednesday 16 June 2004

Grover disease (GD), benign papular acantholytic dermatosis, transient acantholytic dermatosis, persistent acantholytic dermatosis


Definition: Grover’s disease (GD) is a polymorphic, pruritic, papulovesicular dermatosis characterized histologically by acantholysis with or without dyskeratosis.

Once confirmed, most cases of Grover’s disease last six to twelve months, which is why it was originally called "transient". Unfortunately it may last much longer. Nevertheless, it is not to be confused with relapsing linear acantholytic dermatosis.


4 histological patterns:

- focal acantholytic dyskeratosis as in Darier disease
- Hailey-Hailey disease pattern
- pemphigus vulgaris or pemphigus foliaceus pattern
- spongiotic dermatitis pattern

Any or all four patterns may be present. Nonspecific immunofluorescence pattern.

Differential diagnosis

- Darier disease
- Hailey-Hailey disease
- pemphigus vulgaris or pemphigus foliaceus
- spongiotic dermatitis