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nodal cat scratch disease

Monday 23 June 2003

Definition: Cat scratch disease (CSD) is typically a self-limited regional lymphadenopathy in children and young adults that is caused by Bartonella henselae. The majority of CSD cases resolve spontaneously; however, many systemic complications have been described.


- nodal Cat scratch disease: follicular hyperplasia, microabcesses with palisading histiocytes.

Digital case

- HPC:293 : Nodal cat scratch disease

The key pathologic process in cat scratch disease (CSD) usually involves a B-cell-associated granulomatous reaction.

Histologically, CSD appears to exhibit a histopathologic diversity, including suppurative lesions without epithelioid cell granulomas (early lesion), in which the microabscesses were surrounded by monocytoid B-cells (MBCs), suppurative granulomas containing MBCs (intermediate lesion), and suppurative granulomas without MBCs (late lesion).


  • In early lesions, numerous clusters of PMO were detected in the MBCs.
  • In intermediate lesions, both MBCs and PMOs were found to be decreased in number, while late lesions contained no or only a few MBCs and PMOs.

See also

- cat scratch disease
- Adenitis


- Kojima M, Morita Y, Shimizu K, Itoh H, Masawa N, Nakamura S. Plasmacytoid monocytes in cat scratch disease with special reference to the histological diversity of suppurative lesions. Pathol Res Pract. 2006;202(1):17-22. PMID: 16352403