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TCF3
MIM.147141 19p13.3
Tuesday 8 June 2004
Pathology
TCF3/PBX1 fusion gene by t(1;19)(q23;13.3) in B-lineage acute lymphoblastic leukemia
- The t(1;19)(q23;p13.3) is one of the most common chromosomal abnormalities in B-cell precursor acute lymphoblastic leukemia (BCP-ALL).
TCF3/HLF fusion gene by t(17;19)(q22;13.3) in B-lineage acute lymphoblastic leukemia
TCF3/TFPT fusion gene 19p rearrangements in some cases of pediatric pre-B-cell acute lymphoblastic leukemia (pre-B ALL) (11700047, 10086727, 10644725)
t(13;19)(q14;p13) involving TCF3
t(12;19)(p13;p13) involving TCF3
Additional rare, and sometimes cytogenetically cryptic, translocations involving the TCF3 gene have also been described.
References
Barber KE, Harrison CJ, Broadfield ZJ, Stewart AR, Wright SL, Martineau M, Strefford JC, Moorman AV. Molecular cytogenetic characterization of TCF3 (E2A)/19p13.3 rearrangements in B-cell precursor acute lymphoblastic leukemia. Genes Chromosomes Cancer. 2007 May;46(5):478-86. PMID: 17311319
