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CEBPA

MIM.116897

Monday 31 May 2004

C/CAAT enhancer binding protein alpha (C/EBPα) is a bZIP transcription factor involved in cell cycle control and cellular differentiation, which makes this gene a good tumor suppressor (TSGs).

Function

- CCAAT/enhancer-binding protein- (C/EBP) is a transcription factor that coordinates cellular differentiation with growth arrest.
- C/EBP represses the E2F transcription factor.

Pathology

C/EBPα (CEPBA) has been shown to be silenced in some cancer types. For example, C/EBPα silencing by mutations substantially contributes to the malignant transformation evidenced in acute myeloid leukemia (AML). More recently, epigenetic mechanisms have been found to regulate C/EBPα expression in non-small cell lung cancer (NSCLC).

- Specific mutations in the CEPBA gene that encodes the multifunctional transcription factor C/EBP are frequently associated with acute myeloid leukaemias.

  • Patients with acute myeloid leukaemia carry specific combinations of point mutations in the gene encoding C/EBP.
  • Patient-derived C/EBP mutants generally loose the ability to bind DNA or to repress E2F activity.
  • C/EBP expression inhibits the malignant potential of myeloid leukaemia cells by inducing their differentiation.
    E2F repression and DNA binding by C/EBP are required for the C/EBP-induced differentiation of leukaemia cells.
  • Reconstituting C/EBP-mediated E2F repression has the potential to revert leukaemogenesis in vivo.

- More recently, epigenetic mechanisms have been found to regulate C/EBPα expression in non-small cell lung cancer (NSCLC).

References

- Nerlov C. C/EBPalpha mutations in acute myeloid leukaemias.
Nat Rev Cancer. 2004 May;4(5):394-400. PMID: 15122210