Home > E. Pathology by systems > Digestive system > Liver and pancreatobiliary system > Liver > giant cell transformation
giant cell transformation
Thursday 19 June 2003
Digital slide
Case 108 (HPC:108) : Giant cell transformation of hepatocytes
Case 55 (HPC:55) : Giant cell transformation of hepatocytes in cholestatic cirrhosis
Etiology
viral hepatitis
- cytomegalovirus hepatitis (CMV hepatitis)
- rubella virus hepatitis
- herpes simplex virus hepatitis (HSV hepatitis)
- HPV
- HHV-6 hepatitis
- varicella hepatitis
- coxsackievirus hepatitis
- echovirus hepatitis
- reovirus 3 hepatitis
- parvovirus B19 hepatitis
- HIV hepatitis
- enterovirus hepatitis
- paramyxovirus hepatitis
- hepatitis A
- hepatitis B
- hepatitis C (rare)
bacterial hepatitis
- generalized bacterial sepsis
- syphilis (syphilitic hepatitis)
- listeriosis hepatitis
- tuberculosis (tuberculous hepatitis)
parasitic hepatitis (protozoan hepatitis)
- toxoplasmosis hepatitis
Cholestasis
- extra-hepatic biliary atresia
- choledochal cyst
- intrahepatic bile duct paucity (biliary ductopenia) and Alagille disease
- hepatic cystic fibrosis
- familial intrahepatic cholestatic syndromes (FIHC)
- bile acid synthetic diseases (inborn errors of bile acid synthesis)
chromosomal anomalies
- trisomy 21
- trisomy 18
- monosomy X
metabolic diseases
- alpha-1-antitrypsin deficiency
- galactosemia
- Niemann-Pick diseases
- Gaucher diseases
- mucolipidoses
- cerebrohepatorenal syndrome (Zellweger syndrome)
- acute tyrosinemia
- some mitochondriopathies
- some peroxysomopathies
autoimmune diseases (immunohemolytic diseases)
autoimmune hemolytic anemia (GCHAIHA)
- autoimmune hepatitis type II (LKM1+) (1)
- neonatal erythematosus lupus - systemic lupus (1,2,3)
cardiovascuar diseases
- endocardial cushion defect
- anomalous pulmonary venous return
neonatal hemochromatosis (fetal massive hepatic necrosis)
Associations
neonatal hemochromatosis (idiopathic iron storage syndrome)
Arnold-Chiari malformation
See also
neonatal hepatitis
syncitial cells
