CD81

CD81 is a tetraspanin cell surface protein that regulates CD19 expression in B lymphocytes and enables hepatitis C virus infection of human cells.

Immunohistologic analysis in normal hematopoietic tissue showed strong staining for CD81 in normal germinal center B cells, a cell type in which its increased expression has not been previously recognized.

Pathology

 CD81 is a candidate tumor suppressor gene in human gastric cancer. (23264205)

 lymphomas

• By flow cytometry, CD81 is expressed in diffuse large B-cell lymphoma cells independent of the presence or absence of CD10, another germinal center B-cell marker.
• The detection of CD81 in routine biopsy samples and its differential expression in lymphoma subtypes, particularly diffuse large B-cell lymphoma, warrant further study to assess CD81 expression and its role in the risk stratification of patients with diffuse large B-cell lymphoma.

References

 CD81 is a candidate tumor suppressor gene in human gastric cancer. Yoo TH, Ryu BK, Lee MG, Chi SG. Cell Oncol (Dordr). 2012 Dec 21. PMID: 23264205

 CD81 protein is expressed at high levels in normal germinal center B cells and in subtypes of human lymphomas. Luo RF, Zhao S, Tibshirani R, Myklebust JH, Sanyal M, Fernandez R, Gratzinger D, Marinelli RJ, Lu ZS, Wong A, Levy R, Levy S, Natkunam Y. Hum Pathol. PMID: 20004001