FOXA2

Definition : Foxa2 (Hnf3beta) is a winged-helix/forkhead transcription factor that regulates gene expression in the liver, pancreatic islets and adipocytes. It is required for the maintenance of glucose and lipid homeostasis.

Function

 FOXA2 controls PDX1 gene expression in pancreatic beta-cells in vivo (12145169)

Pathology

 FOXA2 is a sensitive and specific marker for small cell neuroendocrine carcinoma of the prostate. (28621319)

Animal models

 Hyperinsulinemia-mediated inactivation of Foxa2 by nuclear exclusion has recently been implicated in the development of liver steatosis and insulin resistance in three animal models of diabetes.

Open references

 FOXA2 is a sensitive and specific marker for small cell neuroendocrine carcinoma of the prostate.
Park JW, Lee JK, Witte ON, Huang J.
Mod Pathol. 2017 Sep;30(9):1262-1272. doi : 10.1038/modpathol.2017.44
PMID: 28621319 Free

References

 Wang H, Wollheim CB. Does chasing selected ’Fox’ to the nucleus prevent diabetes? Trends Mol Med. 2005 Jun;11(6):262-5. PMID: 15949766