penile squamous cell carcinoma

Definition: Penile squamous cell carcinoma is considered a disease of local-regional dissemination.

Images

 Usual type squamous cell carcinoma of the penis (a non-HPV-related squamous cell carcinoma)

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Widespread metastases occur in less than one third of patients. Local recurrence after limited surgical excision or partial penectomy is not uncommon, and it is noted in slow-growing verruciform tumors, intermediate grade superficially spreading lesions, and in poorly differentiated neoplasms.

Etiology

 HPV-associated penile squamous cell carcinoma

References

 The basaloid cell is the best tissue marker for human papillomavirus in invasive penile squamous cell carcinoma: a study of 202 cases from Paraguay. Cubilla AL, Lloveras B, Alejo M, Clavero O, Chaux A, Kasamatsu E, Velazquez EF, Lezcano C, Monfulleda N, Tous S, Alemany L, Klaustermeier J, Muñoz N, Quint W, de Sanjose S, Bosch FX. Am J Surg Pathol. 2010 Jan;34(1):104-14.PMID: 20035150

 Histologic Grade in Penile Squamous Cell Carcinoma: Visual Estimation Versus Digital Measurement of Proportions of Grades, Adverse Prognosis With any Proportion of Grade 3 and Correlation of a Gleason-like System With Nodal Metastasis. Chaux A, Torres J, Pfannl R, Barreto J, Rodriguez I, Velazquez EF, Cubilla AL. Am J Surg Pathol. 2009 Apr 18. PMID: 19384189

 The Prognostic Index: A Useful Pathologic Guide for Prediction of Nodal Metastases and Survival in Penile Squamous Cell Carcinoma. Chaux A, Caballero C, Soares F, Guimarães GC, Cunha IW, Reuter V, Barreto J, Rodríguez I, Cubilla AL. Am J Surg Pathol. 2009 Apr 18. PMID: 19384188

 Velazquez EF, Soskin A, Bock A, Codas R, Barreto JE, Cubilla AL. Positive resection margins in partial penectomies: sites of involvement and proposal of local routes of spread of penile squamous cell carcinoma. Am J Surg Pathol. 2004 Mar;28(3):384-9. PMID: 15104302