Home > E. Pathology by systems > Endocrine system > Parathyroids > parathyroid tumors
parathyroid tumors
Tuesday 27 April 2004
Images
- https://twitter.com/AdamGomezMD/status/695688052711116800
- https://twitter.com/aakasharmand/status/737983217077256192
Digital cases
JRC:15047 : Parathyroid adenoma, with bizarre cells
JRC:18765 : Parathyroid carcinoma
JRC:9410 : Parathyroid carcinoma
Types
parathyroid hyperplasia
parathyroid adenoma
parathyroid carcinoma
Synopsis
parathyroid carcinoma
- increased mitoses
- vascular invasion
- broad bands of fibrosis
Molecular biology
allelic loss regions
- 1p LOH
- 1q25 LOH
- 7q13.3 LOH
- 10q23 LOH
- 11p15.5 LOH
- 13q14.3 LOH
benign parathyroid diseases (adenomas and hyperplasia) had low mean fractional allelic loss (11% and 15%) (16006799)
parathyroid carcinomas (63%) (16006799)
References
Parathyroid tumors and related disorders. DeLellis RA. Mod Pathol. 2011 Apr;24 Suppl 2:S78-93. doi : 10.1038/modpathol.2010.132 PMID: 21455204 [Free]
Haven CJ, Howell VM, Eilers PH, Dunne R, Takahashi M, van Puijenbroek M, Furge K, Kievit J, Tan MH, Fleuren GJ, Robinson BG, Delbridge LW, Philips J, Nelson AE, Krause U, Dralle H, Hoang-Vu C, Gimm O, Morreau H, Marsh DJ, Teh BT. Gene expression of parathyroid tumors: molecular subclassification and identification of the potential malignant phenotype. Cancer Res. 2004 Oct 15;64(20):7405-11. PMID: 15492263
Hunt JL, Carty SE, Yim JH, Murphy J, Barnes L. Allelic loss in parathyroid neoplasia can help characterize malignancy. Am J Surg Pathol. 2005 Aug;29(8):1049-55. PMID: 16006799
Erickson LA, Jalal SM, Harwood A, Shearer B, Jin L, Lloyd RV. Analysis of Parathyroid Neoplasms by Interphase Fluorescence In Situ Hybridization. Am J Surg Pathol. 2004 May;28(5):578-584. PMID: 15105644
