ALK+ anaplastic large cell lymphoma

ICD-9:200.6

ICD-0:M9714/3

eMedicine:1099272

MeSH:D017728

Digital Case

 HPC:190 : ALK+ anaplastic large cell lymphoma (ALK+ ALCL)
 HPC:341 : ALK+ anaplastic large cell lymphoma (ALK+ ALCL)

Synopsis

 2%-7% of non-Hodgkin lymphomas

Immunochemistry

 CD30+
 EMA+ (50%)
 P53+

Variants

 monomorphic ALCL
 small cell ALCL
 lymphohistiocytic ALCL
 Hodgkin-like ALCL
 sarcomatoid ALCL
 neutrophil-rich ALCL
 eosinophil-rich ALCL
 signet-ring ALCL

Associations

 HIV infection

Differential diagnosis

 classic Hodgkin lymphoma

• syncitial variant of sclerosing nodular Hodgkin lymphoma
• lymphocyte depletion Hodkgkin lymphoma

 sinusoidal CD30-positive large B-cell lymphoma (10757332)
 HHV-8-associated lymphoma (15105661)
 Carcinomas
 melanoma

Molecular biology

 fusion genes invoving the ALK gene

• NPM1/ALK fusion protein (70-80%) by t(2;5)(p23;q35)
• TPM3/ALK fusion protein (20%) by t(1;2)(q25;p23)
• MSN/ALK fusion protein by t(X;22)(q11;p23)
• ATIC/ALK fusion protein by inv(2)(p23q35)
• TFG/ALK fusion protein by t(2;3)(p23;q21)
• CLTC/ALK fusion protein by t(2;17)(p23;q23)
• ALO17/ALK fusion protein by t(2;17)(p23;q25)
• MYH9/ALK fusion protein t(2;22)(p23;q11.2)

Links

 AGCOH

See also

 cutaneous CD30+ anaplastic large-cell lymphoma (cutaneous CD30+ ALCL)

References

 Anaplastic Large Cell Lymphoma Associated With Breast Implants: A Report of 13 Cases. Aladily TN, Medeiros LJ, Amin MB, Haideri N, Ye D, Azevedo SJ, Jorgensen JL, de Peralta-Venturina M, Mustafa EB, Young KH, You MJ, Fayad LE, Blenc AM, Miranda RN. Am J Surg Pathol. 2012 Jul;36(7):1000-1008. PMID: 22613996

 Vassallo J, Lamant L, Brugieres L, Gaillard F, Campo E, Brousset P, Delsol G. ALK-positive anaplastic large cell lymphoma mimicking nodular sclerosis Hodgkin’s lymphoma: report of 10 cases.Am J Surg Pathol. 2006 Feb;30(2):223-9. PMID: 16434897

 Allory Y, Merabet Z, Copie-Bergman C, Lange F, Yiou R, Gaulard P. Sarcomatoid variant of anaplastic large cell lymphoma mimics ALK-1-positive inflammatory myofibroblastic tumor in bladder. Am J Surg Pathol. 2005 Jun;29(6):838-9; PMID: 15897755

 Nakamura S, Shiota M, Nakagawa A, Yatabe Y, Kojima M, Motoori T, Suzuki R, Kagami Y, Ogura M, Morishima Y, Mizoguchi Y, Okamoto M, Seto M, Koshikawa T, Mori S, Suchi T. Anaplastic large cell lymphoma: a distinct molecular pathologic entity: a reappraisal with special reference to p80(NPM/ALK) expression. Am J Surg Pathol. 1997 Dec;21(12):1420-32. PMID: 9414185