small cell lung carcinoma

Small-cell lung cancer (SCLC) is an aggressive lung tumor subtype with poor prognosis. Over 95% of patients with small-cell lung cancer (SCLC) die within five years of diagnosis.

Images

 Wikimedia: Lung small cell carcinoma - Diff-Quick cytology

Videos

 Small cell lung carcinoma (by Washington Deceit)

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Sequencing

 Evidences for inactivation of TP53 and RB1 have been found. (22941188)
 Recurrent mutations in the CREBBP, EP300 and MLL genes that encode histone modifiers. (22941188)
 Mutations in PTEN, SLIT2 and EPHA7. (22941188)
 Focal amplifications of the FGFR1 tyrosine kinase gene. (22941188)

A study implicates histone modification as a major feature of SCLC. (22941188)

References

 Small Cell Lung Cancer: Can recent advances in biology and molecular biology be translated into improved outcomes? Bunn PA Jr, Minna J, Augustyn A et al. J Thorac Oncol. 2016 Jan 29. pii: S1556-0864(16)00335-X. doi : 10.1016/j.jtho.2016.01.012 PMID: 26829312

 Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Peifer M, Fernández-Cuesta L, Sos ML et al. Nat Genet. 2012 Oct;44(10):1104-10. PMID: 22941188

 Hann CL, Rudin CM. Fast, hungry and unstable: finding the Achilles’ heel of small-cell lung cancer. Trends Mol Med. 2007 Apr;13(4):150-7. PMID: 17324626

 Wistuba II, Gazdar AF, Minna JD. Molecular genetics of small cell lung carcinoma. Semin Oncol. 2001 Apr;28(2 Suppl 4):3-13. PMID: 11479891