pancreatic acinar cell carcinoma

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 pancreatic acinar cell carcinoma

• https://twitter.com/KUSAURAP/status/578069039697633280
• https://twitter.com/RMeunierMD/status/584066836867735553
• https://twitter.com/KUSAURAP/status/738741327391653888
• https://twitter.com/mreyesm/status/713393408094683136
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• https://twitter.com/CaDxPath/status/847705934612672516

Synopsis

 monotounous acini with mild atypia.

Differential diagnosis

 pancreatic endocrine tumors
 solid-pseudopapillary tumors
 pancreatoblastoma
 ductal adenocarcinoma
 acinar cell adenoma
 focal acinar cell transformation
 microglandular carcinoma

Variants

 pancreatic mixed acinar-endocrine carcinoma (15290275)
 pancreatic acinar cell carcinomas with prominent ductal differentiation (mixed acinar ductal carcinoma and mixed acinar endocrine ductal carcinoma (20182344)
 acinar cell carcinoma of the pancreas metastatic to the ovary (18724247)

Immunochemistry

IHC stains are BCL10, trypsin. Chromogrnain -.

Molecular biology

 frequent allelic loss on chromosome 11p (50%)
 alterations in the APC/beta-catenin pathway (23.5%)

• beta-catenin mutations
• APC truncations
   no K-ras mutation (8031464)

Allelotype: 11072247

1p36.31	4q26-31.1	17p13	11q	13q	15q15-22.1	3q	6q	8q	18q	21q
>70%	>70%	>70%	60%-70%	60%-70%	60%-70%	50%-60%	50%-60%	50%-60%	50%-60%	50%-60%

CGH (comparative genomic hybridization) (10862035)

gains	1q42	12p11.2	Xq12-21
losses	16p13.2-p13.1	16q23

See also

 pancreatic tumors
 pancreatic acinar tumors

References

 Pancreatic acinar cell carcinomas with prominent ductal differentiation: Mixed acinar ductal carcinoma and mixed acinar endocrine ductal carcinoma. Stelow EB, Shaco-Levy R, Bao F, Garcia J, Klimstra DS. Am J Surg Pathol. 2010 Apr;34(4):510-8. PMID: 20182344

 Acinar cell carcinoma of the pancreas metastatic to the ovary: a report of 4 cases. Vakiani E, Young RH, Carcangiu ML, Klimstra DS. Am J Surg Pathol. 2008 Oct;32(10):1540-5.PMID: 18724247