membranous glomerulonephritis

Images

 Membranous nephropathy: H&E, IgG fluorescence, Jones silver, and electron microscopy

• https://twitter.com/Williamson_SR/status/684106160069160960

Synopsis

 thickening of glomerular basal membranes
 subepithelial immune deposits
 no increase in mesangial cell numbers
 IF: diffuse granular deposits along the GBM

• positivity for lgG and often C3 (sometimes low level of staining for IgM or IgA).

Ultrastructure

 early subepithelial deposits

See also

 nephropathies / renal diseases

• glomerulopathies

References

 M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. Beck LH Jr, Bonegio RG, Lambeau G, Beck DM, Powell DW, Cummins TD, Klein JB, Salant DJ. N Engl J Med. 2009 Jul 2;361(1):11-21. PMID: 19571279

 Molecular pathomechanisms of membranous nephropathy: from Heymann nephritis to alloimmunization. Ronco P, Debiec H. J Am Soc Nephrol. 2005 May;16(5):1205-13. PMID: 15800120