Salivary gland neoplasms comprise less than 2% of all tumors in humans and 3% of all head and neck tumors. 80% of them are benign and only 20% are malignant.

Salivary gland neoplasms are relatively uncommon, with an overall incidence of 2.5 to 3 cases per 100,000 persons in the Western world.

The majority of these lesions (approximately 70%–80%) originate in the parotid gland.

Malignant salivary gland tumors are considerably less common; they account for approximately 3% to 5% of all head and neck cancers and have a tendency to present in the sixth or seventh decades of life.

Classification WHO 2017 - Tumours of the salivary glands

salivary epithelial benign tumors : salivary gland adenomas

pleomorphic adenoma (mixed tumor )
salivary myoepithelioma
salivary basal cell adenoma
Warthin tumor (papillary cystadenoma lymphomatosum )
salivary oncocytoma
salivary canalicular adenoma
salivary sebaceous adenoma
salivary lymphadenoma (sebaceous / non-sebaceous )
salivary cystadenoma
salivary ductal papillomas
- salivary inverted ductal papilloma
- salivary intraductal papilloma
- siladenoma papilliferum

malignant epithelial tumors : salivary gland carcinomas

salivary acinic cell adenocarcinoma
salivary mucoepidermoid carcinoma
polymorphous low-grade adenocarcinoma
salivary clear cell adenocarcinoma (NOS)
salivary basal cell adenocarcinoma
salivary sebaceous carcinoma
salivary sebaceous lymphadenocarcinoma
salivary cystadenocarcinoma
salivary oncocytic carcinoma
salivary duct carcinoma
salivary gland adenocarcinoma (NOS)
salivary myoepithelial carcinoma
salivary carcinoma ex pleomorphic adenoma
salivary carcinosarcoma
metastasizing pleomorphic adenoma
salivary squamous cell carcinoma
salivary small cell carcinoma
salivary large cell carcinoma
salivary lymphoepithelial carcinoma
sialoblastoma

NON-WHO 2017 entities

mammary analogue secretory carcinoma (MASC)
salivary cystadenocarcinoma
salivary lymphadenocarcinoma
salivary adenoid cystic carcinoma
salivary mucinous adenocarcinoma
malignant mixed tumor
salivary carcinosarcoma
salivary adenosquamous carcinoma
salivary epithelial-myoepithelial carcinoma
salivary small cell undifferenciated carcinoma (neuroendocrine features) (14763575)
salivary gland anlage tumor (SGAT)

- salivary mesenchymal tumors

osteoclast-type giant cell neoplasm of salivary gland
salivary hemangioma
salivary lipoma
salivary lymphangioma
salivary malignant schwannoma
salivary hemangiopericytoma
salivary malignat fibrous histiocytoma

- salivary lymphomas
- salivary metastatic tumors

Images

- salivary gland epithelial tumors

salivary epithelial benign tumors

pleomorphic adenoma (mixed tumor)
- http://www.webpathology.com/case.asp?case=111

Warthin tumor (papillary cystadenoma lymphomatosum)
salivary basal cell adenoma
- http://www.webpathology.com/case.asp?case=115

salivary myoepithelioma
- http://www.webpathology.com/case.asp?case=120

salivary canalicular adenoma
salivary oncocytoma
- http://www.webpathology.com/case.asp?case=114

salivary cystadenoma
salivary sebaceous adenoma
siladenoma
salivary lymphadenoma
salivary ductal papillomas
- salivary intraductal papilloma
- salivary inverted ductal papilloma
- siladenoma papilliferum

salivary epithelial malignant tumors

salivary acinic cell adenocarcinoma
- http://www.webpathology.com/case.asp?case=117

salivary basal cell adenocarcinoma
- http://www.webpathology.com/case.asp?case=115

salivary clear cell adenocarcinoma
salivary cystadenocarcinoma
salivary sebaceous adenocarcinoma
salivary lymphadenocarcinoma
salivary adenoid cystic carcinoma
- http://www.webpathology.com/case.asp?case=118

salivary mucinous adenocarcinoma
malignant mixed tumor
- http://www.webpathology.com/case.asp?case=112

salivary carcinosarcoma
salivary squamous cell carcinoma
salivary mucoepidermoid carcinoma
- http://www.webpathology.com/case.asp?case=119

salivary adenosquamous carcinoma
salivary epithelial-myoepithelial carcinoma
salivary oncocytic carcinoma
- http://www.webpathology.com/case.asp?case=114

salivary duct carcinoma
salivary myoepithelial carcinoma
salivary small cell undifferenciated carcinoma (neuroendocrine features) (14763575)
salivary gland anlage tumor (SGAT)

- salivary mesenchymal tumors

osteoclast-type giant cell neoplasm of salivary gland
salivary hemangioma
salivary lipoma
salivary lymphangioma
salivary malignant schwannoma
salivary hemangiopericytoma
salivary malignat fibrous histiocytoma

- salivary lymphomas
- salivary metastatic tumors

Immunochemistry

Review and Updates of Immunohistochemistry in Selected Salivary Gland and Head and Neck Tumors. 2016

http://www.archivesofpathology.org/doi/pdf/10.5858/arpa.2014-0167-RA

Variants

pediatric salivary tumors

Diagnosis

epithelial tumors

benign epithelial tumors
- myoepithelioma
- basal cell adenoma
- Warthin tumor
- oncocytoma
- canalicular adenoma
- lymphadenoma : sebaceous lymphadenoma / non-sebaceous lymphadenoma
- cystadenoma
- ductal papilloma
  - intraductal papilloma
  - sialadenoma papilliferum

malignant epithelial tumors
- acinic cell carcinoma
- mucoepidermoidcarcinoma
- adenoid cystic carcinoma
- polymorphous low-grade adenocarcinoma
- epithelial-myoepithelial carcinoma
- clear cell carcinoma, NOS
- basal cell adenocarcinoma
- malignant sebaceous tumors (sebaceous carcinoma , sebaceous lymphadenocarcinoma )
- cystadenocarcinoma
- low-grade cribriform cystadenocarcinoma
- mucinous adenocarcinoma
- oncocytic carcinoma
- salivary duct carcinoma
- adenocarcinoma , NOS
- myoepithelial carcinoma
- carcinoma ex pleomorphic adenoma
- carcinosarcoma
- squamous cell carcinoma
- small cell carcinoma
- large cell carcinoma
- lymphoepithelial carcinoma
- sialoblastoma

mesenchymal tumors

soft tissue tumors

mixed tumors

pleomorphic adenoma
metastasizing pleomorphic adenoma

secondary tumors

Fusion genes in salivary tumors

PLAG1 rearrangements in pleomorphic adenoma

PLAG1-TCEA1
PLAG1-CTNNB1
PLAG1-LITR

MAML2-TORC1 in MEC, WAT, clear cell hidradenoma

MYB-NFIB in ACC, dermal cylindroma

ATF1-EWSR1 in clear cell carcinoma

Links

Atlas of Salivary Gland Tumors by Faramarz Naeim, MD (UCLA)

See also

salivary glands
salivary gland pathology
salivary gland anomalies

pediatric epithelial salivary gland tumors

Open References

Immunohistochemical Analysis of Salivary Gland Tumors: Application for Surgical Pathology Practice. 2012. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496863/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496863/
https://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb9/bb9-chap5.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692207/
http://www.archivesofpathology.org/doi/full/10.5858/arpa.2016-0259-SA

Presentations

http://www.rosaicollection.org/pdfs/sem1354.pdf
http://www.ucsfcme.com/2017/MAP17001A/slides/18_Jordan_Salivary%20.pdf

Paywall References

Pediatric epithelial salivary gland tumors: Spectrum of histologies and cytogenetics at a Children’s Hospital. Craver RD, Fonseca P, Carr R. Pediatr Dev Pathol. 2010 Jan 7. PMID: 20055685