Humpath.com - Human pathology

Home > E. Pathology by systems > Skin > vesiculobullous and acantholytic reaction pattern

vesiculobullous and acantholytic reaction pattern

Thursday 11 February 2021

vesiculobullous and acantholytic reaction patterns

|PO|

Anomalies

- spongiosis: accumulation of extracellular fluid within epidermis with resultant separation of keratinocytes

  • eczematous dermatitis
  • allergic contact dermatitis
  • miliaria

- acantholysis: loss of appropriate keratinocyte cell-cell contact

  • pemphigus
  • transient acantholytic dermatosis
  • Hailey-Hailey
  • Darier disease
  • Grover disease / transient acantholytic dermatosis
  • irritant dermatitis

- reticular degeneration: ballooning degeneration with secondary rupture and death of the keratinocytes

- cytolysis : disruption of keratinocytes due to friction or heat

  • EB simplex
  • epidermolytic hyperkeratosis
  • friction blister

- basement membrane zone disruption or destruction from primary structural deficiencies, humoral and cellular immunologic damage

See also

- cutaneous lesional patterns