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osseous histiocytic tumors
Monday 4 May 2020
histiocytic tumors of bone
Types
osseous benign fibrous histiocytoma
osseous Langerhans histiocytosis
osseous juvenile xanthogranuloma
Differential diagnosis
The bone marrow is a preferential site for both reactive and neoplastic histiocytic proliferations.
The differential diagnosis ranges from :
reactive histiocyte hyperplasia
- systemic infections ,
- vaccinations ,
- storage diseases ,
- post myeloablative therapy, due to increased cell turnover,
hemophagocytic lymphohistiocytosis ,
extranodal Rosai-Dorfman disease
neoplasms derived from histiocytes, including :
- histiocytic sarcomas (HS),
- Langerhans cell histiocytoses (LCH),
- Erdheim-Chester disease (ECD),
- disseminated juvenile xanthogranuloma (JXG).
Open references
Histiocytic cell neoplasms involving the bone marrow
