membrane trafficking

Membrane traffic occurs by vesicular transport between successive compartments of the secretory pathway.

Coat complexes function to collect cargo from donor membranes and deform them to generate transport vesicles with a diameter of 60-80 nm.

Anomalies of membrane traffic

 impaired membrane trafficking
 defective ether lipid biosynthesis (11152660)
 mutations in vesicle-associated proteins

• VAPB mutations in amyotrophic lateral sclerosis (ALS8)

See also

 VAMPs
 SNAREs
 VAPs

References

 Palmer KJ, Stephens DJ. Biogenesis of ER-to-Golgi transport carriers: complex roles of COPII in ER export. Trends Cell Biol. 2004 Feb;14(2):57-61. PMID: 15106609

 Strickland LI, Burgess DR. Pathways for membrane trafficking during cytokinesis. Trends Cell Biol. 2004 Mar;14(3):115-8. PMID: 15055200

 Boes M, Cuvillier A, Ploegh H. Membrane specializations and endosome maturation in dendritic cells and B cells. Trends Cell Biol. 2004 Apr;14(4):175-83. PMID: 15066635