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Enteropathy-like indolent NK cell proliferation in the gallbladder

Monday 6 January 2020

Natural killer (NK) cell enteropathy is a lymphoproliferative disorder, initially described by Mansoor and colleagues, that presents in the gastrointestinal tract, and is often mistaken for extranodal NK/T-cell lymphoma on first assessment. This population of cells in this process have an NK-cell phenotype (CD3, CD56, CD2, CD7), lacks evidence of Epstein-Barr virus infection, has germline rearrangement of the T-cell receptor, and a very indolent clinical course.

An indolent lymphoproliferative disorder with features that resemble NK-cell enteropathy has also been encountered in the female genitourinary tract and in the gallbladder.

Paywall references

- An Enteropathy-like Indolent NK-Cell Proliferation Presenting in the Female Genital Tract. Krishnan R, Ring K, Williams E, Portell C, Jaffe ES, Gru AA. Am J Surg Pathol. 2019 Oct 11. doi : 10.1097/PAS.0000000000001387 PMID: 31609783