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uterine mesenchymal tumors

Wednesday 10 July 2019

Uterine mesenchymal tumors are genetically heterogenous; those with uniform cytomorphology, best exemplified by endometrial stromal tumors, often contain various fusion genes.

Novel fusions involving ESR1 and GREB1 , key factors in sex hormone pathways, have been implicated in rare uterine mesenchymal tumors.

Particularly, the fusions between 5’-ESR1/GREB1 and 3’-NCOA2/NCOA3 were recently identified in 4 uterine tumors resembling ovarian sex-cord tumor (UTROSCT).