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GREB1

Wednesday 10 July 2019

WKP

Definition : Growth regulation by estrogen in breast cancer 1 is a protein that in humans is encoded by the GREB1 gene. This gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Pathology

- GREB1-rearranged uterine sarcomas with variable sex-cord differentiation.

Paywall references

- Clinicopathologic Characterization of GREB1-rearranged Uterine Sarcomas With Variable Sex-Cord Differentiation. Lee CH, Kao YC, Lee WR, Hsiao YW, Lu TP, Chu CY, Lin YJ, Huang HY, Hsieh TH, Liu YR, Liang CW, Chen TW, Yip S, Lum A, Kuo KT, Jeng YM, Yu SC, Chung YC, Lee JC. Am J Surg Pathol. 2019 Jul;43(7):928-942. doi : 10.1097/PAS.0000000000001265 PMID: 31094921