- Human pathology

Home > D. General pathology > Blood and immunity > NLRP3 inflammasome

NLRP3 inflammasome

Wednesday 1 May 2019

NALP3 inflammasome

Members of the nucleotide-binding domain and leucine-rich repeat (LRR)-containing (NLR) family and the pyrin and HIN domain (PYHIN) family can form multiprotein complexes termed ’inflammasomes’.

The biochemical function of inflammasomes is to activate caspase-1, which leads to the maturation of interleukin 1 beta (IL-1β) and IL-18 and the induction of pyroptosis, a form of cell death.

Unlike other inflammasomes, the NLRP3 inflammasome can be activated by diverse stimuli.

The importance of the NLRP3 inflammasome in immunity and human diseases has been well documented, but the mechanism and regulation of its activation remain unclear.

Open references

- Mechanism and Regulation of NLRP3 Inflammasome Activation. He Y, Hara H, Núñez G. Trends Biochem Sci. 2016 Dec;41(12):1012-1021. doi : 10.1016/j.tibs.2016.09.002 PMID: 27669650 Free