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p16+ branchial cleft cyst
Saturday 28 September 2019
p16–can be positive in benign entities like branchial cleft cyst. But p16INK4a is not a reliable surrogate marker for HPV infection in branchial cleft cysts.
Nota bene : High-risk human papillomavirus (HPV) DNA has been reported to be present in branchial cleft cysts, but further information is required to clarify the role of HPV infection in branchial cleft cysts. (30008839) Infection with high-risk HPV types can be observed in branchial cleft cysts.
Differential diagnosis
metastasis of p16+ SCC
See also
branchial cleft cyst
- p16- branchial cleft cyst
Open references
p16(INK4A) immunohistochemical staining may be helpful in distinguishing branchial cleft cysts from cystic squamous cell carcinomas originating in the oropharynx. Pai RK, Erickson J, Pourmand N, Kong CS. Cancer. 2009 Apr 25;117(2):108-19. doi : 10.1002/cncy.20001 PMID: 19365840
Paywall refererences
Case report of a p16INK4A-positive branchial cleft cyst. McLean T, Iseli C, Amott D, Taylor M. J Laryngol Otol. 2015 Jun;129(6):611-3. doi : 10.1017/S0022215114003223 PMID: 26004639
