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Home > A. Molecular pathology > CTHRC1


Saturday 23 February 2019


Definition : Collagen triple helix repeat containing 1 is a protein that in humans is encoded by the CTHRC1 gene.

The CTHRC1 protein may play a role in the cellular response to arterial injury through involvement in vascular remodeling.


- Collagen triple helix repeat containing 1 (CTHRC1) is overexpressed in different kinds of cancer tissues and may thus promote tumor formation.

- Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively, spliced transcript variants have been described.

- Elevated CTHRC1 expression is an indicator for poor prognosis and lymph node metastasis in cervical squamous cell carcinoma CSCC.

  • CTHRC1 overexpression strongly is associated with IFGO stage, histologic grade, depth of stromal infiltration, lymphovascular space invasion, lymph node metastasis, and recurrence.
  • CTHRC1 overexpression was an independent factor for overall survival and disease-free survival in cervical squamous cell carcinoma.
  • High CTHRC1 positively correlated with lymph node metastasis of cervical squamous cell carcinoma.
  • CTHRC1 may be a valuable biomarker for predicting the prognosis and metastasis of CSCC and a potential therapeutic target for treatment of this disease.
  • doi : 10.1016/j.humpath.2018.10.015