Home > E. Pathology by systems > Reproductive system > Male genital system > Prostate > central zone
central zone
Saturday 9 February 2019
CZ
Definition : CZ surrounds the ejaculatory ducts. The central zone accounts for roughly 2.5% of prostate cancers; these cancers tend to be more aggressive and more likely to invade the seminal vesicles.
Glands of central zone at the base of the prostate can mimic high-grade PIN architecturally.
There is nuclear crowding and pseudostratification with tufted, papillary and even cribriform areas within the glands.
Central zone glands may sometimes be seen at the end of a prostate biopsy core admixed with smooth muscle of bladder neck.
They lack nuclear enlargement and hyperchromasia and don’t have prominent nucleoli.
