Home > A. Molecular pathology > IHC markers > S-100
S-100
Monday 22 January 2018
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See also : S100s
Positive staining in normal cells
neural crest derived tissue: Schwann cells, melanocytes, glial cells
skin apocrine glands and eccrine glands
adipocytes , chondrocytes , dendritic cells , Langerhans cells , macrophages , myoepithelial cells
some breast epithelial cells
Expression in tumoral cells
adenoid cystic carcinoma
chondroid tumors
chordoma
clear cell sarcoma
dendritic cell tumors
glial tumors
granular cell tumor (Arch Pathol Lab Med 2004;128:771)
Langerhans cell tumors
adipocytic tumors / lipogenic tumors
malignant peripheral nerve sheath tumor MPNST (50%)
melanoma (95%, including desmoplastic and spindle cell tumors); S100- melanomas often had prior S100+ metastases, often are ocular (Hum Pathol 2005;36:1016)
myoepithelial tumors
neural tumors
paragangliomas : sustentacular cells
perivascular epithelioid cell tumors ( angiomyolipoma, clear cell "sugar" tumor , lymphangioleiomyomatosis , PEComas )
sex cord stromal tumors
Also :
histiocytes in mycobacterial spindle cell pseudotumor in lymph nodes
histiocytes in Rosai-Dorfman disease
Diagnostic use
Common marker of neural tissue / lesions and melanoma
S100 differentiate plexiform schwannoma (S100+, Am J Surg Pathol 2005;29:1042) from MPNST (weak / negative / patchy)
Melan-A and MART1 appear to be superior to S100 for evaluating sentinel lymph nodes for melanoma (Am J Surg Pathol 2001;25:1039)
Negative labelling in tumors
fibroblasts , fibroblastic reticulum cells , perineural cells
atypical fibroxanthoma (AFX)
cardiac sarcomas
myofibroblastoma
solitary fibrous tumor (SFT)
xanthoma
