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oral plasma cell granuloma

Wednesday 14 November 2018

Definition : An oral plasma cell granuloma (OPCG) is a rare reactive tumor such as proliferation composed chiefly of plasmacytic infiltrate. Both clinically and histopathologically, it may be misinterpreted as various pathological entities thus necessitating the complete evaluation of patient and proper histopathological and immunohistochemical analysis of the tissue.

Plasma cell granuloma (PCG) is a rare, nonneoplastic lesion consisting of a proliferation of inflammatory cells predominantly plasma cells in a fibrovascular background. It was first described in 1973 by Bahadori and Liebow. PCG primarily occurs in lungs, but nearly all other organs may be involved, including the head and neck region.

Rarely seen in the oral cavity, the lesions are usually single, seen primarily on gingiva, followed by tongue, lips, buccal mucosa, and palate.

PCG of gingiva can be easily mistaken clinically as peripheral giant cell granuloma, pyogenic granuloma or fibrous gingival epulis, thus necessitating the histopathological examination to confirm the diagnosis. However, microscopically, it may masquerade as various plasma cell neoplasms.

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