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BRAF-mutated MMR-proficient adenocarcinoma of the proximal colon
Friday 7 September 2018
BRAF-mutated microsatellite-stable adenocarcinoma of the proximal colon
BRAF-mutated proximal colon adenocarcinomas with proficient DNA mismatch repair have a dismal prognosis with an aggressive clinical course and often display mucinous differentiation, focal signet ring histology, and other adverse histologic features such as lymphatic and perineural invasion and high tumor budding. (22314188)
Paywall references
BRAF-mutated, microsatellite-stable adenocarcinoma of the proximal colon: an aggressive adenocarcinoma with poor survival, mucinous differentiation, and adverse morphologic features. Pai RK, Jayachandran P, Koong AC, Chang DT, Kwok S, Ma L, Arber DA, Balise RR, Tubbs RR, Shadrach B, Pai RK. Am J Surg Pathol. 2012 May;36(5):744-52. doi : 10.1097/PAS.0b013e31824430d7 PMID: 22314188