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Friday 20 April 2018

Vaginal intraepithelial neoplasia (VAIN)


Definition: Vaginal intraepithelial neoplasia (VAIN) is defined as presence of squamous cell dysplasia without invasion.

VAIN is classified in a similar manner to CIN:
- VAIN 1: mild dysplasia
- VAIN 2: moderate dysplasia
- VAIN 3: severe dysplasia / carcinoma in situ

It is classified according to the depth of epithelial involvement:
- VAIN 1 involves lower one third of epithelium
- VAIN 2 involves lower two thirds of epithelium
- VAIN 3 involves more than two thirds of epithelium

Carcinoma in situ, which encompasses the full thickness of the epithelium, is included under VAIN 3.

Low grade VAIN comprises VAIN 1 and high grade includes VAIN 2 and 3.

See also

- VINs VIN : vulvar intraepithelial neoplasia (VIN)