- Human pathology

Home > E. Pathology by systems > Reproductive system > Female genital system > Vulva > differentiated vulvar intraepithelial neoplasia

differentiated vulvar intraepithelial neoplasia

Thursday 19 April 2018

- differentiated vulvar intraepithelial neoplasia p16-

  • "simplex" or "differentiated type", negative for HPV and affecting elderly women.
  • Premenopausal women are more likely to get usual type VIN, associated with HPV.
  • Postmenopausal women are more likely to get differentiated (aka simplex) type VIN, associated with vulvar dermatoses.
  • VIN, differentiated type is associated with vulvar dermatoses such as lichen sclerosus, and is HPV negative, p16 (INK4A) negative.
  • It tends to have high p53 indices, and MIB-1 expression is more confined to the basal layer.
  • Differentiated (simplex) VIN: Postmenopausal, vulvar dermatoses, HPV negative and p16 negative, high p53, MIB-1 basally.