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differentiated vulvar intraepithelial neoplasia
Thursday 19 April 2018
differentiated vulvar intraepithelial neoplasia p16-
- "simplex" or "differentiated type", negative for HPV and affecting elderly women.
- Premenopausal women are more likely to get usual type VIN, associated with HPV.
- Postmenopausal women are more likely to get differentiated (aka simplex) type VIN, associated with vulvar dermatoses.
- VIN, differentiated type is associated with vulvar dermatoses such as lichen sclerosus, and is HPV negative, p16 (INK4A) negative.
- It tends to have high p53 indices, and MIB-1 expression is more confined to the basal layer.
- Differentiated (simplex) VIN: Postmenopausal, vulvar dermatoses, HPV negative and p16 negative, high p53, MIB-1 basally.
