Home > E. Pathology by systems > Reproductive system > Female genital system > Vulva > differentiated vulvar intraepithelial neoplasia
differentiated vulvar intraepithelial neoplasia
Thursday 19 April 2018
uVIN; usual type VIN
| WKP | PO |
Definition : Vulvar intraepithelial neoplasia (VIN) is "usual type" or "classic type", related to human papillomavirus (HPV) infection and affecting relatively young women.
The usual type includes warty type, basaloid type and mixed (warty and basaloid) type.
The usual type is HPV associated - it is positive for p16, negative or has low indices for p53, and MIB-1 is strongly positive above the basal layer.
VIN, usual type (including the sub-categories warty type and basaloid type) are associated with HPV.
They are HPV and p16 positive, negative for p53, and MIB-1 is strongly positive above the basal layer.
Usual VIN (warty and basaloid types): Premenopausal, HPV positive, p16 positive, low / negative p53, MIB-1 suprabasal.
See also
