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genital inflammatory myofibroblastic tumor

Monday 26 March 2018

Inflammatory Myofibroblastic Tumors of the Female Genital Tract

Inflammatory myofibroblastic tumor (IMT) of the female genital tract is under-recognized. Some ALK-positive IMT has been previously diagnosed as gynecologic smooth muscle tumors.

IMTs may closely mimic gynecologic smooth muscle tumors. IMTs account for at least 5 of 1747 (0.3%) tumors previously diagnosed as leiomyoma and 1 of 44 (2.3%) as leiomyosarcoma.

These tumors may be recognized prospectively with awareness of subtle/focal histologic clues, coupled with a low threshold for ALK IHC.

Open references

- Inflammatory Myofibroblastic Tumors of the Female Genital Tract Are Under-recognized: A Low Threshold for ALK Immunohistochemistry Is Required. Pickett JL, Chou A, Andrici JA, Clarkson A, Sioson L, Sheen A, Reagh J, Najdawi F, Kim Y, Riley D, Maidens J, Nevell D, McIlroy K, Valmadre S, Gard G, Hogg R, Turchini J, Robertson G, Friedlander M, Gill AJ. Am J Surg Pathol. 2017 Oct;41(10):1433-1442. doi : 10.1097/PAS.0000000000000909 PMID: 28731868 Free PMC Article