Humpath.com - Human pathology

Home > E. Pathology by systems > Reproductive system > Female genital system > Breast > mammary fat necrosis

mammary fat necrosis

Monday 20 March 2017

Fat necrosis of breast

PO

Microscopy

- partially necrotic adipose tissue
- foamy macrophages
- multinucleated giant cells
- chronic inflammatory cells
- +/- hemosiderin deposits , fibrosis and calcifications
- +/- metaplastic squamous epithelium

Associations

Fat necrosis of breast may be associated with :
- duct ectasia
- fibrocystic change
- trauma (including surgery)
- brachytherapy (Int J Radiat Oncol Biol Phys 2007;69:724), injections of Depixol (J BUON 2002;7:281)
- low molecular weight heparin (Age Ageing 2005;34:193)
- methylene blue dye (Int Semin Surg Oncol 2005;2:26)
- radiotherapy (25% of patients, Radiother Oncol 2010;97:92)
- reconstructive surgery (35% of patients, Plast Reconstr Surg 2009;124:1754)

See also

- mammary anomalies

  • mammary adipose tissue anomalies