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salivary low-grade cribriform adenocarcinoma

Friday 9 February 2018

Low-grade cribriform cystadenocarcinoma of salivary glands

Definition : Low-grade cribriform cystadenocarcinoma (LGCCC) is a recently described rare tumor of salivary gland which exhibits clinically indolent behavior.

This tumor predominantly consists of intraductal components and frequently exhibits papillary-cystic or cribriform proliferation pattern.

Considering the histological features of LGCCC, it should be distinguished with papillocystic variant of acinic cell carcinoma, conventional salivary duct carcinoma, cystadenocarcinoma, polymorphous low-grade adenocarcinoma, carcinoma ex pleomorphic adenoma and mammary analogue secretory carcinoma.

Immunohistochemically, the luminal tumor cells show diffuse expression of CK and S100; p63 and smooth muscle actin displayed a continuous rim of myoepithelial cells around all tumor islets; no myoepithelial cells were admixed with the luminal cells. Both patients were alive with no tumor recurrence or metastasis at follow-up.

Open references

- Low-grade cribriform cystadenocarcinoma of salivary glands: report of two cases and review of the literature. Wang L, Liu Y, Lin X, Zhang D, Li Q, Qiu X, Wang EH. Diagn Pathol. 2013 Feb 18;8:28. doi : 10.1186/1746-1596-8-28 PMID: 23419146 Free