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nasolabial cyst

Thursday 4 January 2018

Nasolabial cysts are relatively uncommon benign extraosseous maxillary lesions.

Nasolabial cyst lining epithelium is characteristically composed of a basal layer of cuboidal cells and a luminal layer of columnar secretory cells with interspersed mucous goblet cells. In addition, areas of multilayered epithelium and squamous metaplasia may be seen.

The cyst stroma is characterized by collagen-rich fibrovascular tissue with variably admixed chronic inflammatory cells.

Basal layer cells express p63 and cytokeratin 5/6, while goblet cells express MUC-2 and MUC-5AC mucins, supporting the notion that nasolabial cysts can be understood as hamartomatous, locally expansile remnants of distal nasolacrimal duct development.


- The nasolabial cyst: a nonodontogenic oral cyst related to nasolacrimal duct epithelium. Toribio Y, Roehrl MH. Arch Pathol Lab Med. 2011 Nov;135(11):1499-503. doi : 10.5858/arpa.2010-0338-RS PMID: 22032581