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composite intestinal adenoma-microcarcinoid

Monday 4 December 2017

Composite intestinal adenoma-microcarcinoid (CIAM) is a rare colorectal lesion that mostly comprises a conventional adenomatous component with a minute proportion of neuroendocrine (NE) component.

Although microcarcinoids are well-recognized in the setting of chronic inflammatory disorders of the gastrointestinal tract, large intestinal microcarcinoids associated with intestinal adenoma are exceedingly rare.

Microcarcinoids found in CIAMs appear to show favorable clinical outcomes regardless of their size, likely due to the absence of submucosal extension and/or increased proliferative activity.

It has been recommended to avoid additional radical surgeries in patients who have endoscopically undergone complete CIAM excision unless they exhibit ominous histologic features such as submucosal extension or increased proliferative activity.

Open references

- Composite intestinal adenoma-microcarcinoid in the colon and rectum: a case series and historical review. Kim MJ, Lee EJ, Kim DS, Lee DH, Youk EG, Kim HJ.
Diagn Pathol. 2017 Nov 7;12(1):78. doi : 10.1186/s13000-017-0665-9
PMID: 29116005